In this phase you point out which risks are to be mitigated and what corrective and preventive action plan you have thought of to achieve this, including a time line. In Tissue Establishments the factors you can most influence are probability (occurrence) and detectability. The factor of severity of consequences is more difficult, because if consequences happen it mostly affects the quality and safety of the tissue, which means that the consequence is as severe as before. For example, consider the risk that a frozen tissue being distributed by air is delayed, with the result that the tissue is thawed. In this case you cannot influence the severity (loss of tissue) but you can influence the occurrence by taking measures in relation to the amount of dry ice, or the way you transport the tissue, or the detection of the amount of dry ice which was too little to begin with.